Mary’s award-winning transdermal patches are born out of a commitment to accurate dosing through an advanced delivery method. The 2”x2” squares simply adhere to any venous part of the skin for 8-12 hours of unsurpassed, systemic relief. Discreet, convenient and reliable Apply to any venous area of the skin for best results Provides 8-12 hours of unsurpassed, systemic relief High bioavailability 15-30-minute uptake time